Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
Tatyana Kuropatkina, Dmitrii Atiakshin, Fedor Sychev, Marina Artemieva, Tatyana Samoilenko, Olga Gerasimova, Viktoriya Shishkina, Khaydar Gufranov, Natalia Medvedeva, Tyler W LeBaron, Oleg Medvedev · Biomedicines · 2023
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Independent study record
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H2HUBB TAKEAWAY
The results showed that, although hydrogen inhalation had no effect on the main markers of pulmonary hypertension induced by monocrotaline injection, there was a reduction in systemic blood pressure due to its systolic component, and a decrease in TGF-β expression, as well as a reduction in tryptase-containing mast cells. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rats.
How Molecular Hydrogen Was Used
One group of monocrotaline-injected animals was placed in a plastic box that was constantly ventilated with atmospheric air containing 4% of molecular hydrogen, and the two groups of rats, injected with monocrotaline or vehicle, were placed in boxes ventilated with atmospheric air.
What the Researchers Found
The results showed that, although hydrogen inhalation had no effect on the main markers of pulmonary hypertension induced by monocrotaline injection, there was a reduction in systemic blood pressure due to its systolic component, and a decrease in TGF-β expression, as well as a reduction in tryptase-containing mast cells.
H₂ Mechanisms / Biological Findings
Hydrogen has been shown to exhibit selective antioxidant properties against hydroxyl radicals, and exerts antioxidant and anti-inflammatory effects.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.