Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total-layer necrosis: An experimental swine model study.
Yasutaka Tanaka, Yosuke Matsumura, Yosuke Hayashi, Makoto Aoki, Yoshimitsu Izawa, Kazuhiro Endo, Takashi Mato · Acute medicine & surgery · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, body mass was 36.4 (35.1–37.9) and 36.9 (34.4–38.4) kg in the control and hydrogen groups, respectively ( p = 0.89). These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Body mass was 36.4 (35.1–37.9) and 36.9 (34.4–38.4) kg in the control and hydrogen groups, respectively ( p = 0.89).
What the Researchers Studied
The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
The baseline characteristics were compared between the control and hydrogen groups (Table 1 ). Body mass was 36.4 (35.1–37.9) and 36.9 (34.4–38.4) kg in the control and hydrogen groups, respectively ( p = 0.89). The authors concluded that although critically ill conditions can trigger NOMI, the model used in this study did not involve transmural necrosis.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment.
Limitations and Safety
Reported limitations: Despite these limitations, the present study is the first and unique pilot study to evaluate hydrogen inhalation therapy in a NOMI model.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.