RETRACTED: Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer’s disease
Wang Cai, Li Jian, Liu Qiang, Yang Rui, Zhang John H., Cao Yun-Peng, Sun Xue-Jun · Neuroscience Letters · 2011
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “RETRACTED: Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer’s disease” is organized in H2HUBB under the research focus hydrogen-rich saline alzheimer’s disease study 2011. The publication is cited as Wang Cai, Li Jian, Liu Qiang, Yang Rui, Zhang John H., Cao Yun-Peng, Sun Xue-Jun, Neuroscience Letters, 2011. This animal study examined RETRACTED: Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. The abstract describes Rat model; sample size 18; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 10 days. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen-rich saline alzheimer’s disease study 2011 overview
The levels of IL-1β were assessed by ELISA analysis, 8-OH-dG by immunohistochemistry in the brain slides, and JNK and NF-κB by immunohistochemistry and western… Animal research can identify biological effects and support future investigation, but it cannot by itself establish safety or effectiveness in humans.
Study design and hydrogen intervention
Publication type: Animal study. Evidence type: Preclinical animal evidence. Research model or population: Rat model. Sample size: 18. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen-rich saline. Dose or treatment amount: 330 g. Treatment duration: 10 days.
Reported findings and scientific interpretation
For this hydrogen-rich saline alzheimer’s disease study 2011, the study record reports the following: No detailed finding statement was available for this record. Readers should consult the original publication before drawing conclusions.
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Preclinical animal findings may not translate directly to human outcomes.
The intervention or follow-up period appears relatively short.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.