Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism.
Xinwen Kuang, Zhengyun Liang, Yijun Xia, Mengjie Shan, Yan Hao, Hao Liu, Zhi Wang, Qianjun He, Chao Xia, Cheng Feng, Guojing Chang, Youbin Wang · Journal of cellular and molecular medicine · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In In vitro experiments further confirmed its effects on HaCaT keratinocytes, pathway enrichment analysis indicated that biotin metabolism was the potential target pathway. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich medium affected the outcomes measured in In vitro experiments further confirmed its effects on HaCaT keratinocytes. Pathway enrichment analysis indicated that biotin metabolism was the potential target pathway.
What the Researchers Studied
The researchers studied In vitro experiments further confirmed its effects on HaCaT keratinocytes. The study used a in vitro cell-culture laboratory experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 7 days. Pathway enrichment analysis indicated that biotin metabolism was the potential target pathway. Hydrogen-rich medium is reported to have antioxidant and anti-inflammatory effects.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was In vitro experiments further confirmed its effects on HaCaT keratinocytes. The reported sample size was 2. The study used a in vitro cell-culture laboratory experiment. The hydrogen delivery method was hydrogen-rich medium. The reported treatment duration was 7 days.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.