Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway.
Qiao Shi, Kang-Shu Liao, Kai-Liang Zhao, Wei-Xing Wang, Teng Zuo, Wen-Hong Deng, Chen Chen, Jia Yu, Wen-Yi Guo, Xiao-Bo He, Ablikim Abliz, Peng Wang, Liang Zhao · Mediators of inflammation · 2015
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, as shown in Figures 7(d) and 8(c), the expression of I κ B and IL-10 in renal tissues at 12 hours was significantly decreased after SAP ( P < 0.05), but the hydrogen-rich saline treatment induced a significant increase ( P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. As shown in Figures 7(d) and 8(c), the expression of I κ B and IL-10 in renal tissues at 12 hours was significantly decreased after SAP ( P < 0.05), but the hydrogen-rich saline treatment induced a significant increase ( P < 0.05).
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
72 rats were randomly divided into three groups: (1) hydrogen-rich saline treatment group (hydrogen-rich saline group, n = 24) where the rats were administered as a tail intravenously (0.6 mL/100 g) and compensated subcutaneously (2 mL/100 g) with hydrogen-rich saline at 5 min after successful SAP modeling. (2) severe acute pancreatitis model group (SAP group, n = 24) where these rats received an equivalent volume of the normal saline instead of hydrogen-rich saline; (3) Sham operation group (SO group, control, n = 24) where these rats received an equivalent volume of the normal saline after successful sham-operation. As shown in Figures 7(d) and 8(c), the expression of I κ B and IL-10 in renal tissues at 12 hours was significantly decreased after SAP ( P < 0.05), but the hydrogen-rich saline treatment induced a significant increase ( P < 0.05). The authors concluded that some studies also demonstrated that hydrogen-rich saline showed promising efficacy in animal models of several inflammatory diseases including AP [ 13 – 15 ], but there are no reports of hydrogen-rich saline in treating SAP associated acute kidney injury and other extrapancreatic organs injury. Hydrogen (H₂), a new antioxidant, was reported to reduce (•)OH and ONOO(-) selectively and inhibit certain proinflammatory mediators to product, without disturbing metabolic redox reactions or ROS involved in cell signaling. some studies also demonstrated that hydrogen-rich saline showed promising efficacy in animal models of several inflammatory diseases including AP [ 13 – 15 ].
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.