[Influences of hydrogen-rich saline on acute kidney injury in severely burned rats and mechanism].
L L Wang, S X Guo, P Wu, H W Shao, C M Han · Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2018
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Independent study record
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H2HUBB TAKEAWAY
Hydrogen-rich saline reduced renal inflammatory-cytokine expression and improved several kidney-injury measures in severely burned rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined to explore the influences of hydrogen-rich saline on acute kidney injury in severely burned rats and to analyze the related mechanism.
How Molecular Hydrogen Was Used
Immediately after injury, hydrogen-rich saline at the dose of 10 mL/kg were intraperitoneally injected to the rats in hydrogen-rich saline group at one time, while normal saline with the same dose were intraperitoneally injected to the rats in sham injury group and burn group.
What the Researchers Found
Compared with those in burn group, the protein expressions of HMGB1 of rats in hydrogen-rich saline group at PIH 6, 24, and 72 were significantly decreased (P<0.05). The renal injury of rats in hydrogen-rich saline group at different post injury time points were relieved compared with those of rats in burn group at the corresponding time points. The renal tubular injury scores of rats in burn group and hydrogen-rich saline group at PIH 6, 24, and 72 were significantly higher than the score in sham injury group at PIH 72 (P 0.05), the levels of serum creatinine of rats in burn group at all the time points and hydrogen-rich saline group at the other time points were significantly higher than the level of serum creatinine of rats in sham injury group at PIH 72 (P 0.05). The mRNA expression levels of TNF-α, IL-1β, and IL-6 at the other time points in hydrogen-rich saline group were significantly decreased (P 0.05).
H₂ Mechanisms / Biological Findings
Hydrogen-rich saline can alleviate the acute kidney injury in severely burned rats through regulating the release of inflammatory cytokines in renal tissue.
Authors’ Conclusion
The authors concluded that hydrogen-rich saline can alleviate the acute kidney injury in severely burned rats through regulating the release of inflammatory cytokines in renal tissue.