Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation.
Jie Li, Zhijian Hong, Hong Liu, Jihong Zhou, Lei Cui, Siming Yuan, Xianghua Chu, Pan Yu · Frontiers in pharmacology · 2016
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a preliminary study of hydrogen’s protective effect in kidneys, the researchers analyzed kidney morphology and function at 24 h after I/R injury, and the researchers found similar results to previous studies ( Shingu et al., 2010; Wang et al., 2011, 2014 ). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. In a preliminary study of hydrogen’s protective effect in kidneys, the researchers analyzed kidney morphology and function at 24 h after I/R injury, and the researchers found similar results to previous studies ( Shingu et al., 2010; Wang et al., 2011, 2014 ).
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Reported treatment duration: 10 min. In a preliminary study of hydrogen’s protective effect in kidneys, the researchers analyzed kidney morphology and function at 24 h after I/R injury, and the researchers found similar results to previous studies ( Shingu et al., 2010; Wang et al., 2011, 2014 ). The authors concluded that hRSS showed a protective effect in the prevention of renal injury and could promote renal function recovery after I/R injury in rats. Although the mechanisms involved in hydrogen’s protective role remain to be fully elucidated, peritoneal injection of hydrogen could represent an easy to use, safe, cost efficient and effective novel approach for future kidney injury protection. Thus, hydrogen significantly reduced these proinflammatory cytokines in kidney tissue, suggesting that its protective effect on kidney injury might be mediated by the suppression of the intense inflammatory response and its downstream cascade.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The reported treatment duration was 10 min.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.