Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats.
Jiandong Ren, Zhulin Luo, Fuzhou Tian, Qian Wang, Kun Li, Chao Wang · The journal of trauma and acute care surgery · 2012
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In A previously established experimental rat model of TP was generated by controlled delivery of high pressure air impact, plasma cytokines concentrations were reduced in H₂ saline-treated TP rats.
What the Researchers Studied
In this study, the researchers attempted to validate its protective role against traumatic pancreatitis (TP).
How the Study Was Conducted
Human clinical study
How Molecular Hydrogen Was Used
The protective effects of H₂ saline against TP were evaluated in this model system by measuring survival rate and determining changes in histopathology, plasma enzymes, cytokines, and oxidative stress-associated molecules.
What the Researchers Found
Plasma cytokines concentrations were reduced in H₂ saline-treated TP rats.
Authors’ Conclusion
The authors concluded that the findings highlight the potential of H₂-rich saline as a therapeutic agent of trauma-induced AP.