Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.
Mitsunori Ikeda, Kentaro Shimizu, Hiroshi Ogura, Takashi Kurakawa, Eiji Umemoto, Daisuke Motooka, Shota Nakamura, Naotsugu Ichimaru, Kiyoshi Takeda, Shiro Takahara, Shin-Ichi Hirano, Takeshi Shimazu · Shock (Augusta, Ga.) · 2018
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In an animal model, the incidence of bacterial translocation at 24 h after CLP as assessed by cultivation of mesenteric lymph nodes and blood was significantly decreased in the H₂ group versus the control group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as administration of hydrogen-rich saline also prevented the expansion of facultative anaerobic enterobacteriaceae and ameliorated intestinal hyperpermeability at 24 h after clp. these results suggest luminal administration of hydrogen-rich saline, which prevents intestinal dysbiosis, hyperpermeability, and bacterial translocation, could potentially be a new therapeutic strategy in critical illness.
What the Researchers Found
The incidence of bacterial translocation at 24 h after CLP as assessed by cultivation of mesenteric lymph nodes and blood was significantly decreased in the H₂ group versus the control group.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that these results suggest luminal administration of hydrogen-rich saline, which prevents intestinal dysbiosis, hyperpermeability, and bacterial translocation, could potentially be a new therapeutic strategy in critical illness.