Effects of hydrogen-rich saline on endotoxin-induced uveitis.
Wei-Ming Yan, Lei Zhang, Tao Chen, Guan-Hua Zhao, Pan Long, Jing An, Zuo-Ming Zhang · Medical gas research · 2017
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
Hydrogen-rich saline did not obviously ameliorate the signs of uveitis under slit lamp examination and the inflammatory cells infiltration around iris and cilliary body of EIU induced by 1 mg/kg or 1/8 mg/kg of LPS, while DEX significantly reduced the inflammation reflected by the above two indicators (P 0.05), while DEX had an obvious therapeutic effect. These results are preclinical and suggest that molecular hydrogen did not improve the measured outcome. Further human research is needed to determine its clinical relevance.
What the Researchers Studied
The study examined sprague-Dawley rats.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as the therapeutic effects of hydrogen-rich saline have been reported for a wide range of diseases mainly via selectively reducing the amount of reactive oxygen species.
What the Researchers Found
Hydrogen-rich saline did not obviously ameliorate the signs of uveitis under slit lamp examination and the inflammatory cells infiltration around iris and cilliary body of EIU induced by 1 mg/kg or 1/8 mg/kg of LPS (P > 0.05). DEX significantly reduced the inflammation reflected by the above two indicators (P 0.05), while DEX had an obvious therapeutic effect (P < 0.05). However, hydrogen-rich saline exerted an inhibition trend on elevation of protein in AqH of EIU induced by 1 mg/kg of LPS, and significantly reduced the increasing amount of protein in AqH of mild EIU induced by 1/8 mg/kg of LPS (P < 0.05).
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that , hydrogen-rich saline could not obviously mitigate EIU in rats, while it could inhibit the elevation of AqH protein.