Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage.
Bingjie Jiang, Yunping Li, Weimin Dai, An Wu, Huayong Wu, Dandan Mao · Acta cirurgica brasileira · 2021
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Independent study record
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H2HUBB TAKEAWAY
The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
However, the precise role of autophagy in hydrogen-mediated neuroprotection following SAH has not been confirmed.
How Molecular Hydrogen Was Used
In the present study, the objective was to investigate the neuroprotective effects and potential molecular mechanisms of hydrogen-rich saline in SAH-induced EBI by regulating neural autophagy in the C57BL/6 mice model.
What the Researchers Found
The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress That indicates that hydrogen-rich saline-mediated inhibition of autophagy and ER stress ameliorate neuronal death after SAH. The neuroprotective capacity of hydrogen-rich saline is partly dependent on the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway.
H₂ Mechanisms / Biological Findings
The neuroprotective capacity of hydrogen-rich saline is partly dependent on the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway. Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy. However, the precise role of autophagy in hydrogen-mediated neuroprotection following SAH has not been confirmed.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.