Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.
Toyofumi Abe, Xiao-Kang Li, Koji Yazawa, Naoyuki Hatayama, Lin Xie, Bunpei Sato, Yoichi Kakuta, Koichi Tsutahara, Masayoshi Okumi, Hidetoshi Tsuda, Jun-ya Kaimori, Yoshitaka Isaka, Michiya Natori, Shiro Takahara, Norio Nonomura · Transplantation · 2012
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Independent study record
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H2HUBB TAKEAWAY
In the early phases, HRUW solution decreased oxidative stress, tubular apoptosis, and interstitial macrophage infiltration in the kidney grafts. The authors concluded that hRUW solution improved graft function and prolonged graft survival compared with simple cold storage using UW solution by protecting tubular epithelial cells from inflammation and apoptosis. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The researchers investigated whether hydrogen-rich University of Wisconsin (HRUW) solution attenuates renal cold I/R injury.
How Molecular Hydrogen Was Used
The researchers prepared HRUW solution by a novel method involving immersion of centrifuge tubes containing UW solution into hydrogen-saturated water. Hydrogen readily permeates through the centrifuge tubes, and thus, the hydrogen concentration of the UW solution gradually increases in a time-dependent manner.
What Molecular Hydrogen Changed
In the early phases, HRUW solution decreased oxidative stress, tubular apoptosis, and interstitial macrophage infiltration in the kidney grafts.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.