Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.
Fumihiko Hara, Junko Tatebe, Ippei Watanabe, Junichi Yamazaki, Takanori Ikeda, Toshisuke Morita · Circulation journal : official journal of the Japanese Circulation Society · 2016
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
Hydrogen-rich medium reduced TCDD-associated senescence changes in human endothelial cells and was accompanied by Nrf2 activation. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
This study examined the effects of H2on endothelial senescence and clarified the mechanisms involved.
Laboratory Model
Human umbilical vein endothelial cells (HUVECs) were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for various time periods in normal or hydrogen-rich medium.
How Molecular Hydrogen Was Used
Thus, hydrogen-rich water may prove to be an effective anti-aging drink. AND RESULTS: Hydrogen-rich medium was produced by a high-purity hydrogen gas generator.
What Molecular Hydrogen Changed
The baseline H2concentration in hydrogen-rich medium was 0.55±0.07 mmol/L. This concentration gradually decreased, and H2was almost undetectable in medium after 12 h. Hydrogen-rich medium was produced by a high-purity hydrogen gas generator. Human umbilical vein endothelial cells (HUVECs) were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for various time periods in normal or hydrogen-rich medium.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included substantial evidence indicates that molecular hydrogen (H₂) has beneficial vascular effects because of its antioxidant and/or anti-inflammatory effects.
Authors’ Conclusion
Hydrogen-rich water may thus be a functional drink that increases longevity. (Circ J 2016; 80: 2037-2046).