Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females
Michal Botek, Barbora Sládečková, Jakub Krejčí, František Pluháček, Eliška Najmanová · Acta Gymnica · 2011
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 14 healthy participants, ln SDNN was significantly increased after HRW administration when compared to placebo in 45 min (HRW: 4.41 ± 0.42 ms, placebo: 4.28 ± 0.31 ms, p =.049) of rest sitting. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence cardiac autonomic regulation in healthy women.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 14 healthy participants. Ln SDNN was significantly increased after HRW administration when compared to placebo in 45 min (HRW: 4.41 ± 0.42 ms, placebo: 4.28 ± 0.31 ms, p =.049) of rest sitting.
What the Researchers Studied
The researchers studied 14 healthy participants. The study used a double-blind, placebo-controlled, crossover human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 1260 mL hydrogen-rich water per reported dose; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. Ln SDNN was significantly increased after HRW administration when compared to placebo in 45 min (HRW: 4.41 ± 0.42 ms, placebo: 4.28 ± 0.31 ms, p =.049) of rest sitting. The authors concluded that acute HRW ingestion induced a relative increase in sympathetic activ- ity between 25 and 35 min post-ingestion, whereas vagal activity was not affected. molecular hydrogen, autonomic nervous system, heart rate variability, sympathetic activity, time domain indexes ACTA GYMNICA, 2021, Volume 51, Article e2021.009 https://doi.org/10.5507/ag.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence cardiac autonomic regulation in healthy women and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a double-blind, placebo-controlled, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 14 healthy participants. The reported sample size was 14. The study used a double-blind, placebo-controlled, crossover human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen exposure was 1260 mL hydrogen-rich water per reported dose; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at http://gymnica.upol.cz/pdfs/gym/2021/01/09.pdf.