Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in female piglets fed Fusarium mycotoxins contaminated diet.
Xu Ji, Qing Zhang, Weijiang Zheng, Wen Yao · Journal of animal science and biotechnology · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, compared with the MC group, both HRW and LAC treatments attenuated the reduction of villus height in small intestines (duodenum, jejunum, and ileum) caused by Fusarium mycotoxin-contaminated diet ( P < 0.01). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. Compared with the MC group, both HRW and LAC treatments attenuated the reduction of villus height in small intestines (duodenum, jejunum, and ileum) caused by Fusarium mycotoxin-contaminated diet ( P < 0.01).
What the Researchers Studied
The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
For the NC and MC groups, 10 mL/kg body weight (BW) of hydrogen-free water (HFW) was orally administrated to piglets twice daily; while in the MC + LAC and MC + HRW groups, piglets were treated with the same dose of LAC solution (500 mg/kg BW) and HRW twice daily, respectively. Compared with the MC group, both HRW and LAC treatments attenuated the reduction of villus height in small intestines (duodenum, jejunum, and ileum) caused by Fusarium mycotoxin-contaminated diet ( P < 0.01). The authors concluded that the data suggest that orally administrations of HRW and LAC result in less Fusarium mycotoxin-induced apoptosis and leak in the small intestine. Although the underlying mechanisms of the HRW and LAC exert their protective effects on the gut permeability remains unknown, the antioxidative property of molecular hydrogen might shed the light on further discovering the underlying mechanism. Molecular hydrogen has the ability to inhibit I/R-induced oxidative stress and apoptosis and promote epithelial cell proliferation [ 14, 17 ].
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 24. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.