Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function.
Moto Fukai, Sodai Sakamoto, Hiroki Bochimoto, Nur Khatijah Mohd Zin, Kengo Shibata, Takahisa Ishikawa, Shingo Shimada, Norio Kawamura, Masato Fujiyoshi, Sunao Fujiyoshi, Kosei Nakamura, Tsuyoshi Shimamura, Akinobu Taketomi · Transplantation proceedings · 2023
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Independent study record
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H2HUBB TAKEAWAY
In rats, liver enzyme leakage was suppressed by MP (vs control), whereas H₂ treatment did not show a combination effect. These results are preclinical and add to understanding of how molecular hydrogen affects the condition studied. Further human research is needed to determine its clinical relevance.
What the Researchers Studied
The present study aimed to evaluate the effect of H₂ gas treatment during hypothermic machine perfusion (HMP) in rat livers retrieved from donation after circulatory death (DCD) and elucidate the mechanism of action of H₂ gas.
How Molecular Hydrogen Was Used
The graft was subjected to HMP for 3 hours at 7°C using Belzer MPS with or without dissolved H₂ gas.
What the Researchers Found
Liver enzyme leakage was suppressed by MP (vs control), whereas H₂ treatment did not show a combination effect.
Authors’ Conclusion
The authors concluded that in conclusion, HMP and H₂ gas treatment are partly effective in DCD rat livers but insufficient. These results are preclinical and add to understanding of how molecular hydrogen affects the condition studied. Further human research is needed to determine its clinical relevance.