Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men.
Yudai Shibayama, Shohei Dobashi, Takaaki Arisawa, Tamotsu Fukuoka, Katsuhiro Koyama · Medical gas research · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 physically active participants, after exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P < 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P < 0.05), compared with Placebo inhalation. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 8 physically active participants. After exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P < 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P < 0.05), compared with Placebo inhalation.
What the Researchers Studied
The researchers studied 8 physically active participants. The study used a double-blind, placebo-controlled, crossover human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
15 This apparatus can generate 30.0 mL/s gas mixture, consisting of 68.0% hydrogen (hydrogen purity, 99.99%) and 32.0% of oxygen analyzed by gas chromatography (Kureha Analyze Centre Co., Ltd., Fukushima, Japan; Table 2 ). After exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P < 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P < 0.05), compared with Placebo inhalation. The authors concluded that these findings suggested that HG inhalation during post-exercise recovery period might improve exercise performance via reducing systemic oxidative damage. 5 Similarly, a recent animal study demonstrated that acute strenuous exercise under exposure to hydrogen-rich gas reduced postexercise oxidative stress.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a double-blind, placebo-controlled, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 physically active participants. The reported sample size was 8. The study used a double-blind, placebo-controlled, crossover human clinical trial. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
Reported limitations: Although the researchers could not measure directly the hydrogen and oxygen concentrations in the inspired gas due to the technical limitations, the researchers could mathematically estimate it.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.