ineffectiveness of available therapies. Gas-based anticancer approaches are promising, but are hampered by instability and difficulties in targeted delivery. HHOnbs (containing hydrogen (H2), oxygen (O2), and low-dose hydrogen peroxide (H2O2) at the
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Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a laboratory model, hydrogen gas inhibits cell proliferation, induces apoptosis, and suppresses tumor growth in lung cancer (Wang et al., 2018a). These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how hydrogen gas infusion into the tissue-bath preparation was evaluated in this publication and summarizes the source-grounded findings below. Hydrogen gas inhibits cell proliferation, induces apoptosis, and suppresses tumor growth in lung cancer (Wang et al., 2018a).
What the Researchers Studied
The study used a laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Hydrogen gas inhibits cell proliferation, induces apoptosis, and suppresses tumor growth in lung cancer (Wang et al., 2018a). Low -dose hydrogen peroxide, ranging from 50 to 200 µM, can induce cell cycle arrest through the modulation of oxidative stress – related genes in MCF7 breast cancer cells (Chua et al., 2009) and in A549 lung cancer cells by reducing the expression of cyclin D1 and cyclin E (Upadhyay et al., 2007). Consistently, hydrogen-based therapy modulates immune responses, enhances T -cell antitumor function, inhibits T -cell dysfunction, and suppresses ROS – dependent signaling in cancer cells (Zhou et al., 2024).
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The study used a laboratory experiment. The hydrogen delivery method was hydrogen gas infusion into the tissue-bath preparation.
Limitations and Safety
Reported limitations: These limitations can reduce gas levels at the target site (Meng et al., 2025b), while increasing accumulation in other tissues, which may lead to systemic toxicity and adverse effects (Jing et al., 2021).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://jppipa.unram.ac.id/index.php/jppipa/article/download/13858/9293.