Hydrogen Research Study
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Preclinical animal evidenceAnimal studyOther or not reported

Influence of Hydrogen-rich Saline on Hepatocyte Autophagy During Laparoscopic Liver Ischaemia-reperfusion Combined Resection Injury in Miniature Pigs.

Ge Bai, Hui Li, Yansong Ge, Qianzhen Zhang, Jiantao Zhang, Mingzi Chen, Tao Liu, Hongbin Wang · Journal of veterinary research · 2018

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Independent study record

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H2HUBB Research Library branded molecular hydrogen research image
Primary topic Liver and Fatty Liver Disease
Evidence type Preclinical animal evidence
Publication type Animal study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In an animal model, compared with the sham group, the level of autophagy of hepatocytes increased in the IRI and IRI + hydrogen-rich saline groups, corresponding to high oxidative stress and severe liver function injury. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.

What the Researchers Studied

The study examined preclinical animal experiment.

How Molecular Hydrogen Was Used

Eighteen miniature pigs were randomly divided into three groups: a sham operated group (sham group, laparoscopic liver ischaemia-reperfusion combined resection injury group (IRI group), and a hydrogen-rich saline intervention group (IRI + HRS group).

What the Researchers Found

Compared with the sham group, the level of autophagy of hepatocytes increased in the IRI and IRI + hydrogen-rich saline groups, corresponding to high oxidative stress and severe liver function injury. Liver function, antioxidant content, autophagy levels, and liver injury were improved after intervention with hydrogen-rich saline in the IRI + hydrogen-rich saline group compared with the IRI group.

H₂ Mechanisms / Biological Findings

Intervention with hydrogen-rich saline could exert a protective effect against liver ischaemia-reperfusion combined resection injury through the reduction of oxidative stress and hepatocyte autophagy.

Authors’ Conclusion

The authors concluded that intervention with hydrogen-rich saline could exert a protective effect against liver ischaemia-reperfusion combined resection injury through the reduction of oxidative stress and hepatocyte autophagy.