Influence of Hydrogen-rich Saline on Hepatocyte Autophagy During Laparoscopic Liver Ischaemia-reperfusion Combined Resection Injury in Miniature Pigs.
Ge Bai, Hui Li, Yansong Ge, Qianzhen Zhang, Jiantao Zhang, Mingzi Chen, Tao Liu, Hongbin Wang · Journal of veterinary research · 2018
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, compared with the sham group, the level of autophagy of hepatocytes increased in the IRI and IRI + hydrogen-rich saline groups, corresponding to high oxidative stress and severe liver function injury. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
Eighteen miniature pigs were randomly divided into three groups: a sham operated group (sham group, laparoscopic liver ischaemia-reperfusion combined resection injury group (IRI group), and a hydrogen-rich saline intervention group (IRI + HRS group).
What the Researchers Found
Compared with the sham group, the level of autophagy of hepatocytes increased in the IRI and IRI + hydrogen-rich saline groups, corresponding to high oxidative stress and severe liver function injury. Liver function, antioxidant content, autophagy levels, and liver injury were improved after intervention with hydrogen-rich saline in the IRI + hydrogen-rich saline group compared with the IRI group.
H₂ Mechanisms / Biological Findings
Intervention with hydrogen-rich saline could exert a protective effect against liver ischaemia-reperfusion combined resection injury through the reduction of oxidative stress and hepatocyte autophagy.
Authors’ Conclusion
The authors concluded that intervention with hydrogen-rich saline could exert a protective effect against liver ischaemia-reperfusion combined resection injury through the reduction of oxidative stress and hepatocyte autophagy.