Shop Hydrogen Products
Hydrogen Research Study
← Back to Research Library
Preclinical animal evidenceAnimal studyOther or not reported

Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.

Kazuyuki Sakai, Sungsam Cho, Itsuko Shibata, Osamu Yoshitomi, Takuji Maekawa, Koji Sumikawa · Scandinavian cardiovascular journal : SCJ · 2012

View Original Study

Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Cardiovascular Health
Evidence type Preclinical animal evidence
Publication type Animal study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In an animal model, inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.

What the Findings Mean

H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.

What the Researchers Studied

The study used a preclinical animal experiment.

What Effects Did Molecular Hydrogen Have?

The present study was carried out to determine whether inhalation of hydrogen (H(2)) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.

Why These Findings Matter

These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.

How Strong Is This Evidence?

This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.

Technical Study Details

H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment.

Limitations and Safety

No separate limitations or safety findings were identified in the source text available to H2HUBB.

Original Study and H2HUBB Research Context

H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.

CONTINUE EXPLORING

Related Molecular Hydrogen Studies

Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes Induced by Intermittent Hypoxia in Rats.

Ya-Shuo Zhao, Ji-Ren An, Shengchang Yang, Peng Guan, Fu-Yang Yu, Wenya Li, Jie-Ru Li, Yajing Guo, Zhi-Min Sun, En-Sheng Ji · Oxidative medicine and cellular longevity · 2019

The researchers found that H₂-O₂ mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac apoptosis. These preclinical findings add evidence…

Primary topic
Cardiovascular Health
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes. The intervention or follow-up…
Study ID
DOI: 10.1155/2019/7415212
View Study Full Text
Laboratory or cellular evidenceLaboratory StudyOther or not reported

Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats.

Kentaro Noda, Norihisa Shigemura, Yugo Tanaka, Jay Bhama, Jonathan D'Cunha, Hirosuke Kobayashi, James D Luketich, Christian A Bermudez · Transplantation · 2014

In a laboratory model, hydrogen administration also promoted mitochondrial biogenesis and significantly decreased lactate production. The authors concluded that preconditioning lung grafts using inhaled hydrogen attenuated these proinflammatory changes, promoted mitochondrial biogenesis in the…

Primary topic
Cardiovascular Health
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.1097/tp.0000000000000254
View Study View Source
Editorial NoticePreclinical animal evidenceAnimal studyOther or not reported

Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats.

Guoming Zhang, Song Gao, Xiaoyan Li, Lulu Zhang, Hong Tan, Lin Xu, Yaoyu Chen, Yongjian Geng, Yanliang Lin, Benjamin Aertker, Yuanyuan Sun · Scientific reports · 2015

In rats, these data suggested that pharmacological postconditioning with lactic acid and hydrogen rich saline nearly replicates the benefits of mechanical postconditioning. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…

Primary topic
Cardiovascular Health
Delivery method
Other or not reported
Study ID
DOI: 10.1038/srep09858
View Study View Source