Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline.
Zong C, Song G, Yao S, Guo S, Yu Y, Yang N, Guo Z, Qin S. · Lipids in health and disease · 2015
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
Molecular hydrogen produced a favorable primary result in this human study, supporting further research into its potential for diabetes and metabolic health.
Injected hydrogen diabetes metabolic study 2015: what the findings mean
This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. This uncontrolled human study examined Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. The abstract describes Human participants. These findings provided direct evidence supporting the notion that CS exposure in vivo impairs plasma lipid profiles, HDL functionalities and macrophage-to-feces RCT pathway in….
Publication: Zong C, Song G, Yao S, Guo S, Yu Y, Yang N, Guo Z, Qin S., Lipids in health and disease, 2015.
What the researchers studied
Cigarette smoke (CS) exposure impaired plasma lipid profiles by modification of apolipoproteins. Hydrogen (H2) has been proved effective on reducing oxidative stress (an imbalance in which reactive molecules exceed the body’s ability to control them) or improving…
What effects did molecular hydrogen have?
Observed hydrogen effects: Hydrogen (H2) has been proved effective on reducing oxidative stress (an imbalance in which reactive molecules exceed the body’s ability to control them) or improving HDL functionalities in animal models or metabolic syndrome volunteers. This study was undertaken to explore the effects of CS exposure on reverse cholesterol transport (RCT) and the antioxidative effects of H2 treatment against CS exposure in mice transgenic for human cholesteryl ester transfer protein (CETP).Methods[(3)H]-cholesterol-laden macrophages were injected intraperitoneally into mice, and the samples of blood, bile, liver, and feces were collected for radioactivity determination to evaluate RCT. [(3)H]-cholesterol-laden macrophages were incubated with HDL isolated from different groups of mice, and the samples of cell medium supernatants were collected for evaluating the HDL functionality to elicit cholesterol efflux.ResultsCS exposure significantly decreased plasma HDL…
Why these findings matter
The reported benefit supports the therapeutic potential of injected or infused hydrogen for diabetes and metabolic health under the conditions tested. Because people were studied, this is directly relevant to clinical research, but larger independent trials are still needed before hydrogen can be considered an established treatment.
How strong is this evidence?
This is direct human evidence with a comparison group. Comparison or control: Controlled.
Technical study details
- Publication type: Controlled human trial
- Evidence type: Human clinical evidence
- Research model or population: Human participants
- Control or comparison: Controlled
- Hydrogen method: Injected or infused hydrogen
Limitations and safety
Important limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety information: The abstract did not provide detailed safety or adverse-event information.
Original study and H2HUBB research context
This page explains a published research record and does not turn one study into a medical recommendation. Read the original scientific source for the complete methods, statistics, and author conclusions. Compare this result with related evidence in the H2HUBB Molecular Hydrogen Research Library.