Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats.
Takanobu Shigeta, Seisuke Sakamoto, Xiao-Kang Li, Songjie Cai, Chi Liu, Ryosuke Kurokawa, Atsuko Nakazawa, Mureo Kasahara, Shinji Uemoto · Transplantation · 2015
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Independent study record
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H2HUBB TAKEAWAY
In rats, luminal injection of hydrogen-rich solution can reduce oxidative stress and consequently ameliorate ischemic-reperfusion injury. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined the researchers hypothesized that hydrogen-containing solution can be an optimum material for luminal preservation method in SBT.
How Molecular Hydrogen Was Used
Experimental protocols were divided into four groups: sham operation group, no luminal injection (control) group, luminal injection of 5% glucose saline (GS) solution group, and luminal injection of hydrogen-rich GS (HRGS) group.
What the Researchers Found
In rats, luminal injection of hydrogen-rich solution can reduce oxidative stress and consequently ameliorate ischemic-reperfusion injury.
H₂ Mechanisms / Biological Findings
Luminal injection of hydrogen-rich solution can reduce oxidative stress and consequently ameliorate ischemic-reperfusion injury.
Authors’ Conclusion
The authors concluded that luminal injection of hydrogen-rich solution can reduce oxidative stress and consequently ameliorate ischemic-reperfusion injury. Hydrogen-containing solution can be a novel and promising luminal preservation material in SBT.