Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model.
Yutaka Fujii, Mikiyasu Shirai, Shuji Inamori, Akito Shimouchi, Takashi Sonobe, Hirotsugu Tsuchimochi, James T Pearson, Yoshiaki Takewa, Eisuke Tatsumi, Yoshiyuki Taenaka · Artificial organs · 2013
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, although the W/D ratio in the CPB group significantly increased as compared with that in the SHAM group, such an increase was also suppressed significantly in the CPB + H₂ group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What the Researchers Found
In the CPB + H₂ group, however, such increases were significantly suppressed at 60 min after the CPB initiation. Although the W/D ratio in the CPB group significantly increased as compared with that in the SHAM group, such an increase was also suppressed significantly in the CPB + H₂ group.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included the researchers hypothesized that insufflated hydrogen gas (H₂) would provide systemic anti-inflammatory and anti-apoptotic effects during CPB, therefore reducing proinflammatory cytokine levels.
Authors’ Conclusion
The authors concluded that suggest that H₂ insufflation is a possible new potential therapy for counteracting CPB-induced systemic inflammation.