Intestinal hydrogen and nitric oxide gases in preterm infants–effects of antibiotic therapy.
Tanja Sobko, Kristina Elfström, Lars Navér, Jon O Lundberg, Mikael Norman · Neonatology · 2009
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In A minimally invasive tonometric technique was used for repeated measurements (44 samples) of luminal colonic H(2) and NO in 23 preterm infants with gestational age 27-35 weeks, birth weight 1,170-2,99, intestinal H(2) and NO increased during the first week (p < 0.05) to average levels that in the case of H(2), exceeded those of healthy, term infants. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in A minimally invasive tonometric technique was used for repeated measurements (44 samples) of luminal colonic H(2) and NO in 23 preterm infants with gestational age 27-35 weeks, birth weight 1,170-2,99. Intestinal H(2) and NO increased during the first week (p < 0.05) to average levels that in the case of H(2), exceeded those of healthy, term infants.
What the Researchers Studied
The researchers studied A minimally invasive tonometric technique was used for repeated measurements (44 samples) of luminal colonic H(2) and NO in 23 preterm infants with gestational age 27-35 weeks, birth weight 1,170-2,99. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Intestinal H(2) and NO increased during the first week (p < 0.05) to average levels that in the case of H(2), exceeded those of healthy, term infants. The authors concluded that these observations suggest that intestinal measurements of H(2) and NO may be used to monitor birth-related bacterial colonization in relation to postnatal age, maturation and antibiotic therapy.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was A minimally invasive tonometric technique was used for repeated measurements (44 samples) of luminal colonic H(2) and NO in 23 preterm infants with gestational age 27-35 weeks, birth weight 1,170-2,99. The study used a human clinical study.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.