Intravenous hydrogen-rich acetated Ringer’s solution attenuates liver injury in heatstroke rats through endothelial glycocalyx preservation
Ryo Ayata, Motoki Fujita, Yasutaka Oda, Kayoko Harada, Kodai Suzuki, Yasutaka Koga, Masaki Todani, Ryosuke Tsuruta · Scientific Reports · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, both hydrogen-based interventions suppressed high-mobility group box 1 and syndecan-1, preserved endothelial glycocalyx structure, and improved 24-h survival compared with Control. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. Both hydrogen-based interventions suppressed high-mobility group box 1 and syndecan-1, preserved endothelial glycocalyx structure, and improved 24-h survival compared with Control.
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2% source-reported H₂ gas concentration. Both hydrogen-based interventions suppressed high-mobility group box 1 and syndecan-1, preserved endothelial glycocalyx structure, and improved 24-h survival compared with Control. The authors concluded that post-onset intravenous H-AR attenuates heatstroke-associated liver injury, potentially through reduced inflammatory activation and endothelial glycocalyx preservation, and may offer advantages over hydrogen inhalation with respect to hepatoprotection.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The source-reported hydrogen concentration was 2% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.nature.com/articles/s41598-026-64047-0.