Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath.
Takuji Kawamura, Katsuhiko Suzuki, Masaki Takahashi, Miki Tomari, Reira Hara, Yuko Gando, Isao Muraoka · Antioxidants (Basel, Switzerland) · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Similarly, there was no significant difference between the trials at the average bath temperature of one week (H₂ trial: 39.1 ± 1.2 °C; Placebo trial: 38.9 ± 1.0 °C). This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Similarly, there was no significant difference between the trials at the average bath temperature of one week (H₂ trial: 39.1 ± 1.2 °C; Placebo trial: 38.9 ± 1.0 °C).
What the Researchers Studied
The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
H₂ bath or placebo bath were performed for 20 min with a rest of 15 min after cessation of exercise, and VAS measurement and a blood sampling were performed again 5 min and 60 min after bath. From the result of H₂ concentration in exhaled gas, it is believed that H₂ is distributed throughout the body 10 min after H₂ bathing [ 21 ]. Similarly, there was no significant difference between the trials at the average bath temperature of one week (H₂ trial: 39.1 ± 1.2 °C; Placebo trial: 38.9 ± 1.0 °C). The authors concluded that these results suggest that IL-6 may be involved in the mobilization of neutrophils into the peripheral blood and subsequent EIMD and DOMS after downhill running; however, it is not likely that H₂ bath is effective for the inflammatory process that was centered on neutrophils after downhill running.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The reported sample size was 10.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.