Longitudinal In Vivo Immunophenotyping of Regulatory T Cells Following Adjunctive Molecular Hydrogen Therapy in Systemic Lupus Erythematosus.
Chin Liu, Ying-Chen Chen, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Wun-Long Jheng, Kuang-Yih Wang, Feng-Cheng Liu · In vivo (Athens, Greece) · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In Multicolor flow cytometry was performed on peripheral blood mononuclear cells (PBMCs) from the study cohort, the mean SLEDAI-2K score decreased substantially from 9.38±8.33 at the active phase to 1.12±1.46 at stable phase ( p =0.024). These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in Multicolor flow cytometry was performed on peripheral blood mononuclear cells (PBMCs) from the study cohort. The mean SLEDAI-2K score decreased substantially from 9.38±8.33 at the active phase to 1.12±1.46 at stable phase ( p =0.024).
What the Researchers Studied
The researchers studied Multicolor flow cytometry was performed on peripheral blood mononuclear cells (PBMCs) from the study cohort. The study used a laboratory experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Adjunctive molecular hydrogen supplementation was administered to all participants under an approved institutional protocol ( 24 – 27 ), consisting of daily intake of hydrogen-rich coral calcium capsules (170 mg). The mean SLEDAI-2K score decreased substantially from 9.38±8.33 at the active phase to 1.12±1.46 at stable phase ( p =0.024). Traditionally regarded as a biologically inert gas or a selective scavenger of hydroxyl radicals, molecular hydrogen (H₂) has recently been redefined as a potent gaseous signaling molecule with specific molecular targets. hydrogen has been identified as a novel gasotransmitter capable of triggering reversible intracellular calcium (Ca 2+ ) transients via the transient receptor potential cation channel subfamily C member 4 (TRPC4)-short transient receptor potential channel 4-associated protein (TRPC4AP) axis.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was Multicolor flow cytometry was performed on peripheral blood mononuclear cells (PBMCs) from the study cohort. The reported sample size was 8. The study used a laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.