Malproduction of endogenous hydrogen gas in COVID-19.
Sergej M Ostojic · Frontiers in cellular and infection microbiology · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The authors found significantly reduced NO and H₂ S concentrations in blood samples of COVID-19 patients compared with healthy controls, and free sulfide levels were highly predictive of COVID-19 infection based on reduced turnover. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. Assessing low dihydrogen along with H₂ supplementation to restore normal levels could be thus combined via theranostic approaches to aid COVID-19 diagnosis and treatment.
What Effects Did Molecular Hydrogen Have?
The authors found significantly reduced NO and H₂ S concentrations in blood samples of COVID-19 patients compared with healthy controls, and free sulfide levels were highly predictive of COVID-19 infection based on reduced turnover. Assessing low dihydrogen along with H₂ supplementation to restore normal levels could be thus combined via theranostic approaches to aid COVID-19 diagnosis and treatment. Since dihydrogen has many important bioactivities, including cytoprotective, antioxidant, anti-inflammatory, and antiapoptotic, its malproduction in COVID-19 might contribute to the disease progression and severity.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence. The reported sample size was 19.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.