Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.
Miroslav Barancik, Branislav Kura, Tyler W LeBaron, Roberto Bolli, Jozef Buday, Jan Slezak · Antioxidants (Basel, Switzerland) · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. The therapeutic potential of molecular hydrogen in the treatment of various diseases may be attributed to several molecular mechanisms.
What the Researchers Studied
The authors reviewed molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.
What Effects Did Molecular Hydrogen Have?
The therapeutic potential of molecular hydrogen in the treatment of various diseases may be attributed to several molecular mechanisms. Current information indicates that the cellular protective effects mediated by molecular hydrogen are attributable to the modulation of cellular antioxidant defenses (antioxidant and cytoprotective genes), including intracellular and extracellular redox signaling. However, the effects of hydrogen on signaling pathways and adaptive cellular responses (e.g., autophagy) are not always unidirectional; both stimulatory and inhibitory effects of molecular hydrogen have been demonstrated. The therapeutic potential of hydrogen is attributed to several major molecular mechanisms. This review focuses on the effects of hydrogen on the cardiovascular and central nervous systems, and summarizes current knowledge about its actions, including the regulation of redox and intracellular signaling, alterations in gene expressions, and modulation of cellular responses (e.g., autophagy, apoptosis, and tissue remodeling).
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.