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Review or synthesisNarrative reviewOther or not reported

Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications.

Yong Ye, Zi-Hang Yu, Liang Nie, Bin Lu, Guo Mu · Molecular biology reports · 2025

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Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Review or synthesis
Publication type Narrative review
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

This narrative review examined the available molecular-hydrogen literature. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.

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Related Molecular Hydrogen Studies

Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas can ameliorate seizure burden during therapeutic hypothermia in asphyxiated newborn piglets.

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In an animal model, the percentage of piglets with an abnormal aEEG background (aEEG-BG), abnormal aEEG-BG+Sz and SE was lower with TH + H₂ than with TH at 24 h after HI insult. These…

Primary topic
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Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.1038/s41390-024-03041-6
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Laboratory or cellular evidenceLaboratory StudyOther or not reported

MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.

Bing Han, Haoxin Zhou, Guang Jia, Yongwei Wang, Zengfu Song, Gang Wang, Shangha Pan, Xuewei Bai, Jiachen Lv, Bei Sun · The FEBS journal · 2016

In a laboratory model, the subsequent in vitro experiments showed that H₂ treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-κB and the expression…

Primary topic
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Delivery method
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Main limitation
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Study ID
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Preclinical animal evidenceAnimal studyhydrogen-rich water

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The results of the Morris water maze test showed that compared with the IR group, the escape latency of the rats in the IR + LHRW group and the IR + HHRW group was…

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Study ID
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