Molecular Hydrogen Attenuates Coronary Vasculitis in a Kawasaki Disease Mouse Model via Modulation of ZAP70 and LCK–Associated Immune Pathways
Kuang-Den Chen, Ying-Hsien Huang, Ken-Pen Weng, Wen Ling Shih, Tsung Ming Yeh, Mindy Ming-Huey Guo, Ho-Chang Kuo · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, human KD transcriptome (HTA 2.0 array) and DNA methylation (Illumina M450 array) datasets were utilized for validation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. Human KD transcriptome (HTA 2.0 array) and DNA methylation (Illumina M450 array) datasets were utilized for validation.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Mice inhaled hydrogen gas (n = 5 per group). Human KD transcriptome (HTA 2.0 array) and DNA methylation (Illumina M450 array) datasets were utilized for validation.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://doi.org/10.2139/ssrn.7308829.