Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
Jianhua Yu, Weiguang Zhang, Rongguo Zhang, Guixing Jiang, Haijun Tang, Xinxian Ruan, Peitu Ren, Baochun Lu · Toxicology letters · 2015
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, apoptosis in cholangiocytes isolated from a rat model of liver ischemia/reperfusion injury indicated that H₂ significantly attenuates ischemia/reperfusion cholangiocyte injury in vivo. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as , the study shows that h₂ protects intrahepatic cholangiocytes from hypoxia/reoxygenation-induced apoptosis in vitro or in vivo, and this phenomenon may depend on activating nrf2 expression.
What the Researchers Found
Apoptosis in cholangiocytes isolated from a rat model of liver ischemia/reperfusion injury indicated that H₂ significantly attenuates ischemia/reperfusion cholangiocyte injury in vivo.
H₂ Mechanisms / Biological Findings
Molecular hydrogen (H₂) has been shown to be effective in protecting various cells and organs against oxidative stress injury. Human liver cholangiocytes were used to determine the potential protective effects of hydrogen against cholangiocyte H/R injury and explore the underlying mechanisms.
Authors’ Conclusion
The authors concluded that , the study shows that H₂ protects intrahepatic cholangiocytes from hypoxia/reoxygenation-induced apoptosis in vitro or in vivo, and this phenomenon may depend on activating Nrf2 expression.