Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy.
Yan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang Xie · BMC anesthesiology · 2024
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In mice, the survival rate of septic mice treated with H₂ was significantly improved, myocardial tissue inflammation was improved, serum cTnI level was decreased, autophagy flux was increased, and mitophagy protein content was decreased (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. The survival rate of septic mice treated with H₂ was significantly improved, myocardial tissue inflammation was improved, serum cTnI level was decreased, autophagy flux was increased, and mitophagy protein content was decreased (P < 0.05).
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2% source-reported H₂ gas concentration. The survival rate of septic mice treated with H₂ was significantly improved, myocardial tissue inflammation was improved, serum cTnI level was decreased, autophagy flux was increased, and mitophagy protein content was decreased (P < 0.05). The authors concluded that hydrogen exerts protective effect against SIC, which may be achieved through the promotion of autophagy and mitophagy. The findings of this study revealed that inhalation of 2% hydrogen at 1 and 6 h respectively after CLP surgery significantly improved the 7-day survival rate of mice, alleviated myocardial tissue edema and inflammatory cell infiltration, and decreased the serum marker of SIC.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.