Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy.
Yan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang Xie · BMC anesthesiology · 2024
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Independent study record
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H2HUBB TAKEAWAY
In mice, the survival rate of septic mice treated with H₂ was significantly improved, myocardial tissue inflammation was improved, serum cTnI level was decreased, autophagy flux was increased, and mitophagy protein content was decreased (P < 0.05). These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
This study aimed to explore the regulatory mechanism by which hydrogen modulates autophagy and its role in hydrogen protection of SIC.
How Molecular Hydrogen Was Used
The mice were randomly divided into 4 groups: Sham, Sham + 2% hydrogen inhalation (H₂), CLP, and CLP + H₂ group. Another four groups of mice were also studied: CLP, CLP + Bafilomycin A1 (BafA1), CLP + H₂, and CLP + H₂ + BafA1 group.
What the Researchers Found
The survival rate of septic mice treated with H₂ was significantly improved, myocardial tissue inflammation was improved, serum cTnI level was decreased, autophagy flux was increased, and mitophagy protein content was decreased (P < 0.05).
Biological or Mechanistic Findings
This study aimed to explore the regulatory mechanism by which hydrogen modulates autophagy and its role in hydrogen protection of SIC.
Authors’ Conclusion
The authors concluded that hydrogen exerts protective effect against SIC, which may be achieved through the promotion of autophagy and mitophagy. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.