The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
Dmitrii Atiakshin, Andrey Kostin, Alexander Alekhnovich, Artem Volodkin, Michael Ignatyuk, Ilya Klabukov, Denis Baranovskii, Igor Buchwalow, Markus Tiemann, Marina Artemieva, Nataliya Medvedeva, Tyler W LeBaron, Mami Noda, Oleg Medvedev · International journal of molecular sciences · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This preclinical study evaluated hydrogen gas in rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rats.
How Molecular Hydrogen Was Used
In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), the researchers had previously explored the impact of inhaled H₂ on lung inflammation and blood pressure. The exposure of H₂ together with monocrotaline (MCT), despite individual differences between animals, tended to decrease the intrapulmonary MC population and the severity of the fibrotic phenotype of the local tissue microenvironment compared to changes in animals exposed to the MCT effect alone. Thus, with MCT exposure, inhaled H₂ has antifibrotic effects involving MCs in the lungs of rats.
What the Researchers Found
The exposure of H₂ together with monocrotaline (MCT), despite individual differences between animals, tended to decrease the intrapulmonary MC population and the severity of the fibrotic phenotype of the local tissue microenvironment compared to changes in animals exposed to the MCT effect alone.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included molecular hydrogen (H₂) has antioxidant, anti-inflammatory, and anti-fibrotic effects.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.