Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy.
Asgharzadeh MR, Barar J, Pourseif MM, Eskandani M, Jafari Niya M, Mashayekhi MR, Omidi Y. · 2017
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The publication summarizes the rationale and available evidence for molecular hydrogen, but it does not by itself prove treatment effectiveness.
Molecular hydrogen cancer study 2017: what the findings mean
This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. Introduction: Cancer is an intricate disorder/dysfunction of cells that can be defined as a genetic heterogeneity in human disease. Therefore, it is characterized by several adaptive complex hallmarks. Among them, the pH dysregulation appears as a symbol of aberrant functions within the tumor microenvironment (TME).
How to read this paper: This is a research review that summarizes prior research and the underlying studies. It is not one new clinical trial and does not by itself establish that hydrogen is an effective treatment.
Publication: Asgharzadeh MR, Barar J, Pourseif MM, Eskandani M, Jafari Niya M, Mashayekhi MR, Omidi Y., 2017.
What the researchers studied
This review aimed to discuss the key molecular changes of tumor cells in terms of bio-energetics and cancer metabolism in relation with pH dysregulation.
What effects did molecular hydrogen have?
What the review reported: This review did not test one new hydrogen treatment in a single participant group. It summarizes hydrogen-related effects reported across the underlying studies. The dysregulation of pH in solid tumors is fundamentally related to the Warburg effect and hypoxia, leading to expression of a number of molecular machineries, including: NHE1, H+ pump V-ATPase, CA-9, CA-12, MCT-1, GLUT-1. This review aimed to discuss the key molecular changes of tumor cells in terms of bio-energetics and cancer metabolism in relation with pH dysregulation.
Why these findings matter
The review helps define the scientific rationale and possible therapeutic potential of molecular hydrogen, but its conclusion is only as strong as the studies it includes. It summarizes the field rather than proving that hydrogen is an effective treatment.
How strong is this evidence?
This is an evidence review that summarizes prior research. Its value depends on the quality, size, consistency, and risk of bias of the underlying studies being summarized.
Technical study details
- Publication type: Narrative review
- Evidence type: Review or synthesis
- Research model or population: Published literature review
- Hydrogen method: Other or not reported
Limitations and safety
Important limitations: Review conclusions depend on the quality, consistency, and heterogeneity of the included studies.
Safety information: The abstract did not provide detailed safety or adverse-event information.
Original study and H2HUBB research context
This page explains a published research record and does not turn one study into a medical recommendation. Read the original scientific source for the complete methods, statistics, and author conclusions. Compare this result with related evidence in the H2HUBB Molecular Hydrogen Research Library.