Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.
Jun Ye, Yuping Li, Takeki Hamasaki, Noboru Nakamichi, Takaaki Komatsu, Taichi Kashiwagi, Kiichiro Teruya, Ryuhei Nishikawa, Takeshi Kawahara, Kazuhiro Osada, Kazuko Toh, Masumi Abe, Huaize Tian, Shigeru Kabayama, Kazumichi Otsubo, Shinkatsu Morisawa, Yoshinori Katakura, Sanetaka Shirahata · Biological & pharmaceutical bulletin · 2008
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
ERW counteracted the effect of A549 cell-conditioned medium and decreased total tube length. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The study examined in vitro cell-culture laboratory experiment.
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What Molecular Hydrogen Changed
ERW counteracted the effect of A549 cell-conditioned medium and decreased total tube length (p<0.01). Numerous reports have demonstrated that the intracellular redox (oxidation/reduction) state is closely associated with the pattern of VEGF expression. Electrolyzed reduced water (ERW) produced near the cathode during the electrolysis of water scavenged intracellular H(2)O(2) and decreased the release of H(2)O(2) from a human lung adenocarcinoma cell line, A549, and down-regulated both VEGF transcription and protein secretion in a time-dependent manner.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.