Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats.
Jing Yang, Shujing Wu, Liqun Zhu, Jingjing Cai, Lu Fu · Molecular medicine reports · 2017
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In rats, hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‐stress marker MDA and expression of NOXs, while increasing the activity of the anti‐oxidant enzyme SOD. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. Hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‐stress marker MDA and expression of NOXs, while increasing the activity of the anti‐oxidant enzyme SOD.
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present study, the effects of hydrogen on pressure overload‐induced cardiac fibrosis and heart failure were investigated in abdominal aortic‐constricted rats. Hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‐stress marker MDA and expression of NOXs, while increasing the activity of the anti‐oxidant enzyme SOD. The authors concluded that these results indicate that HCS treatment can improve cardiac function by reducing interstitial fibrosis in pressure‐overloaded rats through its anti‐oxidative properties and via suppression of TGF-β1 signaling.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.