The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives
M. Nakayama, S. Kabayama, S. Ito · Renal Replacement Therapy · 2016
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. During HD with an H₂-enriched solution (approximately 50 ppb H₂), markers of increased oxidative stress (such as interleukin-6, myeloperoxidase, methemoglobin, increased lymphocyte apoptosis, and high blood pressure) are suppressed. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. During HD with an H₂-enriched solution (approximately 50 ppb H₂), markers of increased oxidative stress (such as interleukin-6, myeloperoxidase, methemoglobin, increased lymphocyte apoptosis, and high blood pressure) are suppressed.
What the Researchers Studied
The authors reviewed the hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives.
What Effects Did Molecular Hydrogen Have?
During HD with an H₂-enriched solution (approximately 50 ppb H₂), markers of increased oxidative stress (such as interleukin-6, myeloperoxidase, methemoglobin, increased lymphocyte apoptosis, and high blood pressure) are suppressed. The authors concluded that these findings indicate that the use of an H₂-enriched solution may prove to be a novel approach to ameliorate dialysis-related complications.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at http://link.springer.com/content/pdf/10.1186/s41100-016-0036-0.