Translational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction.
H. Asanuma, M. Kitakaze · Circulation Journal · 2017
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This publication is a scientific hypothesis or perspective about molecular hydrogen and identifies directions for further research.
Evidence Supporting the Idea
Interestingly, hydrogen (H₂) gas has been reported to provide beneficial therapeutic effects through its reducing capacity, including effects on oxidative stress, inflammation, cell death and metabolism.3 It has been reported that H₂ gas inhalation (HI) during reperfusion reduced infarct size in a rat model of cardiac IR injury.4 Furthermore, it has also been reported that HI during reperfusion reduced infarct size in a canine model of cardiac IR injury via opening of mitochondrial ATP-sensitive K+ channels followed by inhibition of mitochondrial permeability transition pores.5 Because the canine experimental model can evaluate the precise systemic hemodynamics and the contraction/ relaxation kinetics resemble those of humans, it can be assumed that HI would limit infarct size in humans (Figure).
H₂ Mechanisms / Biological Findings
Interestingly, hydrogen (H₂) gas has been reported to provide beneficial therapeutic effects through its reducing capacity, including effects on oxidative stress, inflammation, cell death and metabolism.3 It has been reported that H₂ gas inhalation (HI) during reperfusion reduced infarct size in a rat model of cardiac IR injury.4 Furthermore, it has also been reported that HI during reperfusion reduced infarct size in a canine model of cardiac IR injury via opening of mitochondrial ATP-sensitive K+ channels followed by inhibition of mitochondrial permeability transition pores.5 Because the canine experimental model can evaluate the precise systemic hemodynamics and the contraction/ relaxation kinetics resemble those of humans, it can be assumed that HI would limit infarct size in humans (Figure). single-center, prospective, open-label, rater-blinded study.