Molecular hydrogen is a potential protective agent in the management of acute lung injury.
Yan Zhang, Jin Zhang, Zhiling Fu · Molecular medicine (Cambridge, Mass.) · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. However, a clinical trial showed that inhaling a mixture of 1.2–1.4% molecular hydrogen–air increased urinary 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress, levels. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. However, a clinical trial showed that inhaling a mixture of 1.2–1.4% molecular hydrogen–air increased urinary 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress, levels.
What the Researchers Studied
The authors reviewed molecular hydrogen is a potential protective agent in the management of acute lung injury.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 66.6% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 66.6% source-reported H₂ gas concentration; via nasal cannula. However, a clinical trial showed that inhaling a mixture of 1.2–1.4% molecular hydrogen–air increased urinary 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress, levels. The authors concluded that it can be concluded that molecular hydrogen has a wide therapeutic application spectrum in the treatment of ALI caused by various pathogenetic factors. Table 1 The proposed biological effects of molecular hydrogen Biological effects Main mechanisms References Anti-inflammation Inhibits IL-1β, IL-6, TNF-α, HMGB-1, ICAM-1. Inhibits M1 polarization, increases M2 polarization of macrophages. Inhibits the recruitment of neutrophils to lesion sites, inhibits adhesion of polymorphonuclear neutrophils to ECs; The involved pathways: NF-κB, NLRP3, TLR4, Nrf2 Buchholz et al. ( 2008 ), Kawamura et al. ( 2013 ), Xiao et al. ( 2013 ), Ren et al. ( 2014 ), Chen et al. ( 2015b ), Liu et al. ( 2015a ), Shi et al. ( 2015 ), Xie et al. ( 2015 ), Zhai et al. ( 2015 ), Tian et al. ( 2017 ), Ning et al. ( 2018 ), Yu et al. ( 2019 ), Zou et al. ( 2019 ), Ming et al. ( 2020 ), Yang et al. ( 2020 ), Qiu et al. ( 2021 ) Anti-oxidation Directly scavenges · OH and ONOO −; activates Nrf-2/ HO-1; upregulates the expression of SOD, CAT, GSH-Px, downregulates NADPH oxidase; hormesis through increasing ROS Ohsawa et al. ( 2007 ), Yu and Zheng ( 2012 ), Shinbo et al. ( 2013 ), Hirayama et al. ( 2018 ), Zhao et al. ( 2019 ) Modulates autophagy Promotes autophagy when autophagy is insufficient; inhibits autophagy when excessive autophagy disrupts cell homeostasis Zhang et al. ( 2015 ), Yao et al. ( 2019 ), Chen et al. ( 2020a ), Zhuang et al. ( 2020 ), Qiu et al. ( 2021 ) Modulates cell death Antiapoptosis: inhibiting Bax, caspase-3, and caspase-8, upregulating Bcl-xl and Bcl-2 Inhibits pyroptosis by inhibiting oxidative stress, NLRP3 and mitoKATP/ERK1/2/p38 MAPK signaling pathways Cai et al. ( 2008 ), Kawamura et al. ( 2010 ), Du et al. ( 2016 ), Nie et al. ( 2021 ), Zhang et al. ( 2021 ) ANTI-INFLAMMATORY ACTION: Molecular hydrogen exhibits anti-inflammatory activities in various injury models.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The reported sample size was 2000. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 66.6% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.