Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury.
Jian Tong, Yu Zhang, Pan Yu, Jie Liu, XiaoLiang Mei, Jia Meng · The Journal of surgical research · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In exploring the underlying mechanisms, the researchers found that hydrogen could markedly mitigate the degree of IR-induced ER stress and apoptosis (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in male C57BL/6 mice. In exploring the underlying mechanisms, the researchers found that hydrogen could markedly mitigate the degree of IR-induced ER stress and apoptosis (P < 0.05).
What the Researchers Studied
The researchers studied male C57BL/6 mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
IR was induced by interrupting hind limb blood flow for 3h, followed by 4h of reperfusion, and H₂ was administered by inhalation throughout the reperfusion process. In exploring the underlying mechanisms, the researchers found that hydrogen could markedly mitigate the degree of IR-induced ER stress and apoptosis (P < 0.05). The authors concluded that taken together, these results revealed the protective effect of hydrogen gas on hind limb ischemia reperfusion injury on mice by attenuating oxidative stress, impairing ER stress and apoptosis, and its ability to modulate JNK signaling pathway.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was male C57BL/6 mice. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.