Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.
Hiroyuki Terawaki, Wan-Jun Zhu, Yukie Matsuyama, Tomoyoshi Terada, Yasuhito Takahashi, Kaoru Sakurai, Shigeru Kabayama, Mariko Miyazaki, Noritomo Itami, Ryoichi Nakazawa, Sadayoshi Ito, Seiichi Era, Masaaki Nakayama · Hemodialysis international. International Symposium on Home Hemodialysis · 2014
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In 8 patients, however, the mean proportion of reversibly oxidized albumin in outlet serum was significantly lower than that in inlet serum following the H₂-HD session, whereas no significant changes were found in the standard solution session, suggesting that "intra-dialyzer" OS is reduced by H₂ -HD. This human hemodialysis study evaluated an H₂-enriched solution. Redox or peroxide terminology describes the biological context and does not change the identity of the molecular-hydrogen intervention.
What the Researchers Studied
The study examined 8 patients.
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What the Researchers Found
This study aimed to clarify whether hydrogen (H₂), which is a known antioxidant, is capable of suppressing increased OS induced during HD sessions. Comparison of inlet and outlet blood revealed significant decreases in total glutathione and reduced glutathione, as well as significant increases in hydrogen peroxide in both HD treatments. However, the mean proportion of reversibly oxidized albumin in outlet serum was significantly lower than that in inlet serum following the H₂-HD session, whereas no significant changes were found in the standard solution session, suggesting that "intra-dialyzer" OS is reduced by H₂ -HD.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that , the application of H₂-enriched solutions could ameliorate OS during HD.
H2HUBB Evidence Boundary
This human hemodialysis study evaluated an H₂-enriched solution. Redox or peroxide terminology describes the biological context and does not change the identity of the molecular-hydrogen intervention.