Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress.
Xiaoyin Meng, Hongguang Chen, Guolin Wang, Yonghao Yu, Keliang Xie · Experimental and therapeutic medicine · 2015
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Independent study record
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H2HUBB TAKEAWAY
In female Sprague Dawley rats, hydrogen-rich saline attenuated the FSH release, elevated the level of E2, improved the development of follicles, and reduced the damage to the ovarian cortex at T1, T2 and T3 in the OI + H₂ rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined female Sprague Dawley rats.
How Molecular Hydrogen Was Used
In the OI and OI + H₂ groups, the rats were administered a dose of cisplatin on the 1st and 7th days. The rats in the Con + H₂ and OI + H₂ groups were intraperitoneally injected with hydrogen-rich saline (10ml/kg body weight) once a day over a 2-week period.
What the Researchers Found
Hydrogen-rich saline attenuated the FSH release, elevated the level of E2, improved the development of follicles, and reduced the damage to the ovarian cortex at T1, T2 and T3 in the OI + H₂ rats.
H₂ Mechanisms / Biological Findings
Hydrogen has been reported to exert a therapeutic effect in several diseases due to its antioxidative, anti-inflammatory and anti-apoptotic properties. Cisplatin induced oxidative stress by increasing the levels of oxidation products and attenuating the activity of antioxidant enzyme, which could be reversed by hydrogen-rich saline treatment.
Authors’ Conclusion
The authors concluded that , hydrogen-rich saline exerts a protective effect against cisplatin-induced ovarian injury by reducing MDA and increasing SOD and CAT activity.