Molecular hydrogen promotes wound healing by inducing early extracellular matrix deposition and epidermal stem cell proliferation
Zhao P, Dang Z, Liu M, Guo D, Luo R, Adzavon YM, Zhang M, Xie F, Zhang X, Wang Y, Pan S, Ma X · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The researchers found that a high concentration of H₂ (66% H₂ ) greatly increased the healing rate (3 times higher than the control group) on day 11 post wounding. The authors concluded that have discovered a novel pattern of wound healing induced by molecular hydrogen treatment. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
The researchers found that a high concentration of H₂ (66% H₂ ) greatly increased the healing rate (3 times higher than the control group) on day 11 post wounding.
What the Researchers Studied
The study used a in vitro cell-culture laboratory experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 66% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 66% source-reported H₂ gas concentration; reported treatment duration: 3 days. The researchers found that a high concentration of H₂ (66% H₂ ) greatly increased the healing rate (3 times higher than the control group) on day 11 post wounding. The authors concluded that have discovered a novel pattern of wound healing induced by molecular hydrogen treatment. Hydrogen alleviates inflammatory responses by reducing especially the Th 1 and Th 17 population during aseptic wound healing Inflammation also influences wound healing and matrix deposition 55, 56.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The study used a in vitro cell-culture laboratory experiment. The source-reported hydrogen concentration was 66% source-reported H₂ gas concentration. The reported treatment duration was 3 days.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.researchsquare.com/article/rs-1822552/v1.