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Review or synthesisNarrative reviewOther or not reported

Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation.

Shin-Ichi Hirano, Yoshiyasu Takefuji · Biomedicines · 2024

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Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Review or synthesis
Publication type Narrative review
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

This narrative review examined the available molecular-hydrogen literature. Although H₂ has been reported to reduce the side effects of anticancer drugs in animal studies and clinical trials, the underlying molecular mechanisms remain unclear. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.

Main Findings Across the Literature

Although H₂ has been reported to reduce the side effects of anticancer drugs in animal studies and clinical trials, the underlying molecular mechanisms remain unclear.

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Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

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Preclinical animal evidenceAnimal studyOther or not reported

[Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice].

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