Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage
Liren Qian, Bailong Li, Fei Cao, Yuecheng Huang, Shulin Liu, Jianming Cai, Fu Gao · Nuclear Technology and Radiation Protection · 2010
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage Compared to cells pretreated without hydrogen, the researchers demonstrated that treating cells with hydrogen-rich PBS before irradiation could significantly inhibit IR-induced apoptosis, increase viability of human intestinal crypt cells, significantly increase endogenous antioxidant, and decrease malondialdehyde and 8-hydroxydeoxyguanosine concentrations of human lymphocyte AHH-1 cells. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro.
Laboratory Model
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro.
How Molecular Hydrogen Was Used
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro.
What Molecular Hydrogen Changed
Compared to cells pretreated without hydrogen, the researchers demonstrated that treating cells with hydrogen-rich PBS before irradiation could significantly inhibit IR-induced apoptosis, increase viability of human intestinal crypt cells, significantly increase endogenous antioxidant, and decrease malondialdehyde and 8-hydroxydeoxyguanosine concentrations of human lymphocyte AHH-1 cells.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that it is concluded that hydrogen has a potential as an effective and safe radioprotective agent.