Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats.
Youguo Ying, Haizhou Xu, Min Yao, Zonghe Qin · Journal of orthopaedic surgery and research · 2017
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Independent study record
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H2HUBB TAKEAWAY
In rats, however, after treatment with HSS, all of these changes were alleviated, and these changes were mitigated when treated with HSS by ip then iv injection. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.
How Molecular Hydrogen Was Used
The source material available to H2HUBB did not provide enough detail to identify the molecular hydrogen administration method.
What the Researchers Found
OA increased the levels of MDA, TNF-α, and IL-1β, as well as MPO activity in lung tissues (P < 0.05). However, after treatment with HSS, all of these changes were alleviated (P < 0.05), and these changes were mitigated when treated with HSS by ip then iv injection (P < 0.05). The researchers found decreased PaO2 levels and the pathological changes of lung tissue of ALI after OA injection.
H₂ Mechanisms / Biological Findings
The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.
Authors’ Conclusion
The authors concluded that hSS attenuated ALI induced by OA in rats and might protect against ALI through selective resistance to oxidation and inhibiting inflammatory infiltration.