Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases.
Giovanni Brandi, Chiara Delbaldo, Marzia Deserti, Valeria Relli, Simone Rimedio, Andrea Palloni, Chiara Deiana, Gioconda Saccoccio, Raffaele Ingenito, Simona Tavolari · Ageing research reviews · 2025
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined the available evidence on molecular hydrogen. Recently, the use of molecular hydrogen (H₂) as a preventive and therapeutic approach has been proposed due to its antioxidant and anti-inflammatory properties, its ability to regulate cell senescence and death, and to restore intestinal eubiosis. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
The review examined molecular hydrogen therapy: A "democratic" emerging strategy against aging and age-related diseases.
Main Findings Across the Literature
Recently, the use of molecular hydrogen (H₂) as a preventive and therapeutic approach has been proposed due to its antioxidant and anti-inflammatory properties, its ability to regulate cell senescence and death, and to restore intestinal eubiosis. Although the studies investigating the role of H₂ in slowing-down aging and age-related diseases are still limited, current findings support the idea that its administration may be able to affect different hallmarks of these processes. Current therapeutic approaches to slow down these processes will be also discussed, with a main focus on the potential use of H₂ as an innovative preventive and therapeutic strategy.
H₂ Mechanisms / Biological Findings
Recently, the use of molecular hydrogen (H₂) as a preventive and therapeutic approach has been proposed due to its antioxidant and anti-inflammatory properties, its ability to regulate cell senescence and death, and to restore intestinal eubiosis.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.