Paradigm shift in hydrogen medicine: Target molecules and catalytic mechanisms elucidated at the atomic level.
Motoaki Sano, Masaki Shibuya, Hitoshi Uchinoumi, Yoshinori Katsumata, Kosuke Shirakawa, Zenzo Fujii, Takeshi Yamamoto · Journal of cardiology · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The review reports that Ab initio density functional theory calculations support the notion that H2 does not interfere with normal ferrous heme, but intervenes exclusively in pathologically hyperoxidized heme.
What the Researchers Studied
Source-reported study description: Molecular hydrogen (H2) has been shown to exert antioxidant and anti-inflammatory effects across a broad spectrum of disease models and clinical trials; however, its direct reaction rate with…
Source-reported study description: The present review delineates a paradigm shift that resolves this enigma from three distinct perspectives.
What the Study Found
The authors reported: First, oxidized Fe-porphyrin "hematin [Fe(III)-OH]" has been identified as a redox-related biosensor for H2, reducing •OH selectively to water through a catalytic cycle.
What the Findings Mean
The authors concluded/reported: Ab initio density functional theory calculations support the notion that H2 does not interfere with normal ferrous heme, but intervenes exclusively in pathologically hyperoxidized heme.
Study Details
Publication type: narrative_review
Evidence source level: B_ABSTRACT
Original scholarly source: https://pubmed.ncbi.nlm.nih.gov/42668114/