Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial.
Toru Ishibashi, Kosuke Kawamoto, Kasumi Matsuno, Genki Ishihara, Takamichi Baba, Nobuaki Komori · PloS one · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In To determine the efficacy of H₂ for improving peripheral vascular endothelial function, water containing high H₂ concentrations was administered to participants. The Ln_RHI was measured in the fin, ln_RHI improved by 22.2% (p<0.05) at 24 h after the first ingestion of high H₂ water and by 25.4% (p<0.05) after the daily consumption of high H₂ water for 2 weeks. These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in To determine the efficacy of H₂ for improving peripheral vascular endothelial function, water containing high H₂ concentrations was administered to participants, and the Ln_RHI was measured in the fin. Ln_RHI improved by 22.2% (p<0.05) at 24 h after the first ingestion of high H₂ water and by 25.4% (p<0.05) after the daily consumption of high H₂ water for 2 weeks.
What the Researchers Studied
The researchers studied To determine the efficacy of H₂ for improving peripheral vascular endothelial function, water containing high H₂ concentrations was administered to participants, and the Ln_RHI was measured in the fin. The study used a randomized, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Next, the subjects drank 500 ml of the placebo water or the high H₂ water within 10 min, and after resting for 1 h, the RHI was measured again. After the measurements were obtained, a second drink was administered, and the day after, they drank the placebo or the high H₂ water once each day until the day before the last measurements at 14 days. In total, they drank the high H₂ water or placebo 14 times. Ln_RHI improved by 22.2% (p<0.05) at 24 h after the first ingestion of high H₂ water and by 25.4% (p<0.05) after the daily consumption of high H₂ water for 2 weeks. The authors concluded that daily consumption of high H₂ water improved the endothelial function of the arteries or arterioles assessed by the PAT test.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for metabolic syndrome and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was To determine the efficacy of H₂ for improving peripheral vascular endothelial function, water containing high H₂ concentrations was administered to participants, and the Ln_RHI was measured in the fin. The reported sample size was 8. The study used a randomized, placebo-controlled human clinical trial.
Limitations and Safety
Reported limitations: It was relatively large because of the small sample size.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.