Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial.
Toru Ishibashi, Kosuke Kawamoto, Kasumi Matsuno, Genki Ishihara, Takamichi Baba, Nobuaki Komori · PloS one · 2020
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Independent study record
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H2HUBB TAKEAWAY
In To determine the efficacy of H₂ for improving peripheral vascular endothelial function, water containing high H₂ concentrations was administered to participants, and the Ln_RHI was measured in the fin, ln_RHI improved by 22.2% (p<0.05) at 24 h after the first ingestion of high H₂ water and by 25.4% (p<0.05) after the daily consumption of high H₂ water for 2 weeks.
What the Researchers Studied
In this study, the researchers aimed to investigate the effect of molecular hydrogen (H₂) on reactive hyperemia-PAT of the small arteries of fingers in healthy people.
How the Study Was Conducted
Randomized, placebo-controlled human clinical trial.
How Molecular Hydrogen Was Used
To determine the efficacy of H₂ for improving peripheral vascular endothelial function, water containing high H₂ concentrations was administered to participants, and the Ln_RHI was measured in the finger vasculature. Sixty-eight volunteers were randomly divided into two groups: a placebo group (n = 34) that drank molecular nitrogen (N₂)-containing water and a high H₂ group (n = 34) that drank high H₂ water (containing 7 ppm of H₂: 3.5 mg H₂ in 500-mL water).
What the Researchers Found
Ln_RHI improved by 22.2% (p<0.05) at 24 h after the first ingestion of high H₂ water and by 25.4% (p<0.05) after the daily consumption of high H₂ water for 2 weeks.
Authors’ Conclusion
The authors concluded that daily consumption of high H₂ water improved the endothelial function of the arteries or arterioles assessed by the PAT test.